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The existence of a fluorine atom for the R2' situation with the phenyl ring is a big structural characteristic that is understood to boost the potency of benzodiazepine derivatives compared to their non-fluorinated counterparts
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QSAR models for predicting GABA_A receptor binding affinity are usually built utilizing data from known benzodiazepines and their experimentally decided binding affinities
As an example, in the synthesis of linked triazolobenzodiazepines, intermediates like N-nitrosoamidines or acetyl hydrazone derivatives are used, which then endure more reactions to type the triazole ring
Productive sample preparing is crucial to extract and isolate this compound from complex Organic and seized material matrices, making sure economical and accurate analysis.
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Researchers may well use this solution to investigate its consequences to the central anxious process, GABA receptor modulation, and its possible applications in the fields of neuroscience, pharmacology, and toxicology.
Patent US4155913A outlines cyclization strategies that could require buy fluclotizolam heating intermediates in carboxylic acids, both within the existence of the Alcoholic beverages or without a solvent program, at temperatures starting from area temperature to 300°C
As a constructive allosteric modulator, this compound binds on the benzodiazepine web site around the GABAA receptor, improving GABA's inhibitory results by rising the frequency of chloride channel opening
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